Bioenergetics and cell death
نویسندگان
چکیده
منابع مشابه
Prolonged seizure activity impairs mitochondrial bioenergetics and induces cell death.
The mechanisms underlying neuronal death following excessive activity such as occurs during prolonged seizures are unclear, but mitochondrial dysfunction has been hypothesised to play a role. Here, we tested this with fluorescence imaging techniques in rat glio-neuronal neocortical co-cultures using low Mg(2+) levels to induce seizure-like activity. Glutamate activation of NMDA receptors result...
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FOR HALF A CENTURY, comparative physiology has been profoundly influenced by the Nobel laureate August Krogh’s dictum (4) that “for a large number of problems, there will be some animal of choice with which it can be most conveniently studied.” As one who did research on insect respiration, Krogh would have greatly admired the work of Chamberlin (1) appearing in this issue of the American Journ...
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Circadian clocks are biologic oscillators present in all photosensitive species that produce 24-h cycles in the transcription of rate-limiting metabolic enzymes in anticipation of the light–dark cycle. In mammals, the clock drives energetic cycles to maintain physiologic constancy during the daily switch in behavioral (sleep/wake) and nutritional (fasting/feeding) states. A molecular connection...
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Parkinson's disease is characterized by dopaminergic neurodegeneration and is associated with mitochondrial dysfunction. The bioenergetic susceptibility of dopaminergic neurons to toxins which induce Parkinson's like syndromes in animal models is then of particular interest. For example, rotenone, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its active metabolite 1-methyl-4-phenylpyr...
متن کاملThe Dual Function of Reactive Oxygen/Nitrogen Species in Bioenergetics and Cell Death: The Role of ATP Synthase
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) targeting mitochondria are major causative factors in disease pathogenesis. The mitochondrial permeability transition pore (PTP) is a mega-channel modulated by calcium and ROS/RNS modifications and it has been described to play a crucial role in many pathophysiological events since prolonged channel opening causes cell death. The...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2010
ISSN: 0077-8923
DOI: 10.1111/j.1749-6632.2010.05633.x